Amiodarone-induced thyroid dysfunction.
نویسندگان
چکیده
To purchase electronic or print reprints, contact The InnoVision Group, 101 Columbia, Aliso Viejo, CA 92656. Phone, (800) 809-2273 or (949) 362-2050 (ext 532); fax, (949) 362-2049; e-mail, [email protected]. stated that he did not feel well, and before admission, he had had an episode of unexplained profuse diaphoresis, rapid heart beat, and shortness of breath. He also said that he had lost about 4.5 kg (10 lb) in the preceding 2 months even though his appetite had been good and he had eaten well. His medications before admission included amiodarone 200 mg/d, metoprolol, enalapril, simvastatin, aspirin, folic acid, and warfarin. Upon admission, a 12-lead electrocardiogram showed normal sinus rhythm at a heart rate of 95/min with no acute changes; blood pressure was 140/70 mm Hg. The findings on physical examination were unremarkable. Admission laboratory results were all within the normal reference ranges. Initially, no serum levels of thyroid hormones were determined. Myocardial infarction and heart failure were ruled out, and his preadmission medications were continued. Because Mr W. had somewhat vague signs and symptoms and a history of cardiac disease, he underwent a coronary angiogram. On the basis of the results, he had stenting of a vein graft to the diagonal coronary artery and stenting of the right coronary artery. On the day after placement of the stents, he continued to have intermittent diaphoresis Renate Porsche, APRN, BC, NP Zara R. Brenner, APRN, BC Amiodarone is often used to treat both ventricular and atrial arrhythmias. Although its cardiac side effects are less frequent than those associated with other antiarrhythmics, it has potentially marked effects on thyroid physiology; it can cause both thyrotoxicosis and hypothyroidism. Nursing care of patients receiving amiodarone includes recognizing and monitoring for these potential complications and teaching patients preventive measures to avoid these problems. In this article, we review the pharmacokinetics of amiodarone and the thyroid dysfunctions that can occur as side effects of its use.
منابع مشابه
Risk factors for amiodarone-induced thyroid dysfunction in Japan☆
BACKGROUND Amiodarone is associated with a number of significant adverse effects, including elevated transaminase levels, pulmonary fibrosis, arrhythmia, and thyroid dysfunction. Although thyroid dysfunction is considered to be a common and potentially serious adverse effect of amiodarone therapy, the exact pathogenesis remains unknown because of its complex manifestations. Therefore, the preva...
متن کاملTherapeutic particularities in amiodarone induced thyroid disorder in patients with underlying cardiac condition.
AIM the analysis of therapeutic approach in patients with basic heart condition and amiodarone induced thyroid dysfunction--correlations with the evolution and prognosis. MATERIAL AND METHODS The study included 215 patients, 90 men and 125 women aged between 35 and 87, with different cardiac pathologies hospitalized in the Cardiology Clinic between 2004-2014, who received amiodarone treatment...
متن کاملCurrent concepts Amiodarone-induced thyroid disorders: a clinical review
Although amiodarone is regarded as a highly eVective antiarrhythmic agent, its use may lead to alterations in thyroid gland function and/or thyroid hormone metabolism, partly because of its rich iodine content. Patients treated with amiodarone may manifest altered thyroid hormone profile without thyroid dysfunction, or they may present with clinically significant amiodaroneinduced hypothyroidis...
متن کاملAmiodarone and the thyroid: a practical guide to the management of thyroid dysfunction induced by amiodarone therapy.
Amiodarone induces predictable changes in thyroid function tests that are largely explicable in terms of the physiological effects of iodide excess and inhibition of deiodinase activity. Clinically relevant thyroid dysfunction is not uncommon during amiodarone therapy, and requires careful diagnosis and treatment. The diagnosis and management of thyrotoxicosis is probably best supervised by a s...
متن کاملAmiodarone-induced thyroid dysfunction in a tertiary center in south Brazil.
Amiodarone, used in the treatment of cardiac arrhythmias, is associated with thyroid dysfunction. No reports exist on its frequency in southern Brazil, nor studies evaluating the usefulness of clinical scores to diagnose thyroid abnormalities in these patients. This study aimed at determining the prevalence of amiodarone-induced thyroid dysfunction in a representative sample from a tertiary cen...
متن کامل[Amiodarone-induced thyrotoxicosis].
Amiodarone-induced thyroid dysfunction occurs in about 15-20% of patients under amiodarone therapy. Amiodarone-induced hypothyroidism (AIH) can develop in patients with an apparently normal thyroid gland or in those with an underlying chronic autoimmune thyroiditis. On a clinical ground, AIH is not challenging and can be easily treated with L-thyroxine therapy. Amiodarone-induced thyrotoxicosis...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Critical care nurse
دوره 26 3 شماره
صفحات -
تاریخ انتشار 2006